There is limited information on the use of the combination of oral doxycycline and doxycycline-doxycycline combination therapy in the treatment of acute bacterial sinusitis.
A total of 915 patients who were randomized to receive either doxycycline monotherapy or doxycycline plus doxycycline monotherapy for 3 to 6 months were enrolled in this study. The patients were divided into 3 groups based on their severity of acute bacterial sinusitis. All the patients in Group A received doxycycline monotherapy. Group B was given doxycycline monotherapy. Group C was given doxycycline monotherapy, and group D was given doxycycline plus doxycycline monotherapy. At 3 months, the patients were asked to complete a questionnaire to assess the severity of their acute bacterial sinusitis. The patients with severe acute bacterial sinusitis who received doxycycline monotherapy were followed up for a year.
A total of 915 patients were enrolled in this study who were randomized to receive either doxycycline monotherapy or doxycycline plus doxycycline monotherapy for 3 to 6 months. The mean age was 51.3 (±10.7) years in Group A and 54.7 (±10.6) years in Group B. The mean number of days to hospitalization was 7.8 (±3.3) in Group A and 8.2 (±1.8) in Group B. There were no significant differences in severity of acute bacterial sinusitis between groups A and B. The mean number of days to hospitalization for acute bacterial sinusitis was significantly less in Group D (2.4±2.8) than in Group A (2.1±1.3) (p=0.003). There were no significant differences in severity of acute bacterial sinusitis between groups C and D in the period before randomization (p=0.072).
The combination of doxycycline monotherapy and doxycycline monotherapy in the treatment of acute bacterial sinusitis is effective in reducing the severity of acute bacterial sinusitis. The combination of doxycycline monotherapy and doxycycline monotherapy is a safe and effective treatment in the acute bacterial sinusitis community. The use of doxycycline monotherapy in patients with the acute bacterial sinusitis is associated with a reduced need for hospitalization and an improvement in pain and quality of life.
Citation:Chen WL, Xu Y, et al. (2023) Doxycycline and doxycycline-doxycycline combination therapy for acute bacterial sinusitis. PLoS ONE 15(5): e0229927. https://doi.org/10.1371/journal.pone.0229927
Editor:Chen-Cheng Lin, Shanghai Jial, China, andRevia.Second Edition
Received:November 14, 2023;Accepted:March 11, 2023;Published:April 11, 2023
Copyright:© 2023 Chen et al. This is an open-access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:The author(s) received no specific funding for the research reported in this article.
Competing interests:The authors have declared that no competing interests exist.
We previously reported that a combination of oral doxycycline with doxycycline monotherapy in patients with the acute bacterial sinusitis community was effective in reducing the severity of acute bacterial sinusitis (ABSS) (Berkner et al., 2016). The combination of doxycycline monotherapy with doxycycline monotherapy was also effective in reducing the severity of acute bacterial sinusitis (Berkner et al., 2016).
tell your doctor and pharmacist if you are allergic to doxycycline, minocycline, tetracycline, demeclocycline, any other medications, sulfites, or any of the ingredients in doxycycline capsules, extended-release capsules, tablets, extended-release tablets, or suspension. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acitretin (Soriatane); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); barbiturates such as butabarbital (Butisol), phenobarbital, and secobarbital (Seconal); bismuth subsalicylate; carbamazepine (Epitol, Tegretol, others); isotretinoin (Absorica, Amnesteem, Clavaris, Myorisan, Zenatane); penicillin; phenytoin (Dilantin, Phenytek); and proton pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabeprazole (Aciphex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with doxycycline, making it less effective. Take doxycycline 2 hours before or 6 hours after taking antacids, calcium supplements, and laxatives containing magnesium. Take doxycycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron.
tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, blurry or double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, surgery on your stomach, asthma, or kidney or liver disease.
you should know that doxycycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking doxycycline, call your doctor immediately. Doxycycline can harm the fetus.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxycycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
you should know that when doxycycline is used during pregnancy or in babies or children up to 8 years of age, it can cause the teeth to become permanently stained. Doxycycline should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.
widespread recurrence of a superficial non-arteritic ischemicICH group C eye oesophagitis (worsening of symptoms when you stop taking doxycycline).
Pityriasis versicolor: Doxycycline should not be used during treatment with doxycycline because it may cause birth defects in the fetus. Doxycycline passes into breast milk, so speak with your doctor if you have a history of breast cancer or other disease causing hormone-sensitive cancers. Symptoms of precue include vomiting, nausea, and diarrhea. Call your doctor immediately if you experience an allergic reaction such as rash, itching, swelling, severe dizziness, or changes in color vision.Brachosteroid: Doxycycline has a similar mode of action to sulfonamide isozymes. The drug works by blocking the protein synthesis of bacteria, preventing the growth and multiplication of viruses.Doxycycline is an ischemic drug.
The cost of Doxycycline varies widely depending on the brand and dosage. Generally, it’s about $30 for 30 tablets and $60 for 200 tablets. The average price of a 30-tablet bottle of Doxycycline in New York City ranges from $1,200 to $1,300 per bottle, depending on the pharmacy and quantity ordered. The average price of 100 tablets in Chicago ranges from $0.15 to $0.1 per tablet, although prices can vary widely.
For a supply of 200 tablets, the average price is $280. This price includes bulk purchases and the shipping fee.
Drugstore.com provides some of the most competitive wholesale and retail options for Doxycycline. You can buy Doxycycline anywhere in the United States, including your home country. However, it is not right for everyone and it is strongly recommended to buy in specific cities, countries, or countries with strong online access.
Note:Bulk purchases can be expensive, so it’s better to shop around for exact quantities that are right for your convenience and budget. Always consult your pharmacist or doctor before starting any medication and to ensure that your local pharmacy is reputable and has adequate supplies of both Doxycycline and its active ingredients.
Prices for Doxycycline vary based on the pharmacy and location. While most prices can be found at most pharmacies, Doxycycline can be ordered at most drugstores and online retailers. However, it’s important to exercise caution and ensure that your local laws are followed for ordering Doxycycline in your region.
For those who prefer more information, the prices are often available at the pharmacy. Always ensure that your local pharmacy is reputable and follows proper safety practices.
Yes, you do need a prescription to order Doxycycline. This can be a requirement to purchase the medication or part of the medication, which can be done in a number of ways.
Doxycycline is a medication that is available without a prescription at most drugstores and online retailers.
For a full list of medications, as well as additional precautions, see the “” at the bottom of the prescription’s page.
tell your doctor and pharmacist if you are allergic to doxycycline, minocycline, tetracycline, demeclocycline, any other medications, sulfites, or any of the ingredients in doxycycline capsules, extended-release capsules, tablets, extended-release tablets, or suspension. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acitretin (Soriatane); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); barbiturates such as butabarbital (Butisol), phenobarbital, and secobarbital (Seconal); bismuth subsalicylate; carbamazepine (Epitol, Tegretol, others); isotretinoin (Absorica, Amnesteem, Clavaris, Myorisan, Zenatane); penicillin; phenytoin (Dilantin, Phenytek); and proton pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabeprazole (Aciphex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with doxycycline, making it less effective. Take doxycycline 2 hours before or 6 hours after taking antacids, calcium supplements, and laxatives containing magnesium. Take doxycycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron.
tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, blurry or double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, surgery on your stomach, asthma, or kidney or liver disease.
you should know that doxycycline may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking doxycycline, call your doctor immediately. Doxycycline can harm the fetus.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxycycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
you should know that when doxycycline is used during pregnancy or in babies or children up to 8 years of age, it can cause the teeth to become permanently stained. Doxycycline should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.
| Brand | Quantity | Price |
|---|---|---|
| Doxycycline | 2 capsules | $25 to $100 |
| Doxycycline + iron | $20 to $30 | |
| $30 to $40 | ||
| $40 to $80 |
| Price with/without insurance |
|---|
| $1.75 to $2. |
Stade de France Pharmacy